Assessment of the embryotoxicity of four Chinese herbal extracts using the embryonic stem cell test

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Assessment of the embryotoxicity of four Chinese herbal extracts using the embryonic stem cell test.

Rhizoma Atractylodes macrocephala, Radix Isatidis, Coptis chinensis and Flos Genkwa are common herbal remedies used by pregnant woman in China. In this study, their potential embryotoxicity was assessed using the embryonic stem cell test (EST) and a prediction model. The potential embryotoxicity of the herbs was based on three endpoints: the concentrations of the compounds that inhibited the pr...

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Assessment of Embryotoxicity and Teratogenicity by the Embryonic Stem Cell Test

During pregnancy, a fetus can be affected by exposure to a variety of chemicals and pharmaceuticals. These effects can occur through exposure of the mother and subsequent placental transport. Thus, it is important to assess embryotoxicity (developmental toxicity without the observation of maternal toxicity) and teratogenicity (irreversible structure developmental effects without the observation...

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ژورنال

عنوان ژورنال: Molecular Medicine Reports

سال: 2015

ISSN: 1791-2997,1791-3004

DOI: 10.3892/mmr.2015.3598